연구단계 | 1단계 : 2년차 | ||
논문제목(영문) | Clinical significance of chronic kidney disease and atrial fibrillation on morbidity and mortality in patients with acute myocardial infarction. | ||
국내외구분 | 국외 | SCI여부 | SCI |
연구책임자역활 | 교신저자 | 논문기여율 | 30% |
주저자명 | Hwang HS | ||
교신저자명 | Ahn Y | ||
공동저자명 | Park MW, Yoon HE, Chang YK, Yang CW, Kim SY, Cho JS, Kim CJ, Park GM, Park CS, Choi YS, Koh YS, Lee JM, Shin DI, Seo SM, Jeon DS, Moon KW, Yoo KD, Kim HY, Kim DB, Park HJ, Kim PJ, Chang K, Chung WS, Seung KB, Jeong MH, Her SH | ||
게제년월일 | 2014-10-29 | ||
ISSN | 0250-8095 | ||
Impact Factor | 2.646 | ||
학술지명 | Am J Nephrol | ||
서지사항 | 0집 / 40권 / 4호, 페이지(345 - 352) | ||
병기표기 | 3개 | ||
Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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요약초록문 (Abstract) 입력 |
BACKGROUND/AIMS: Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD and AF on the mortality and morbidity in AMI population has not been determined. METHODS: Between January 2004 and December 2009, a total of 4,738 AMI patients were enrolled prospectively. Patients were divided into four groups according to the combined status of CKD and AF. The primary endpoint was a combination of 5-year major adverse cardiac and cerebrovascular events (MACCE). RESULTS: The prevalence of AF was significantly higher in CKD patients than in non-CKD patients (6.76 vs. 3.31%, p < 0.001). The highest cumulative event rate of MACCE and death was observed in patients with both CKD and AF (68.5 and 64.0%), respectively. In multivariable analyses, compared with patients with neither AF nor CKD, hazard ratios (HR) for composite of MACCE were 1.66 (95% CI, 1.14-2.41), 1.24 (95% CI, 1.06-1.46), and 2.10 (95% CI, 1.42-3.13) for patients with AF only, those with CKD only, and those with both CKD and AF, respectively (p for interaction = 0.935). Patients with both CKD and AF had a greatest risk for all-cause mortality (HR 2.54; 95% CI, 1.60-4.53), and the significant synergistic interaction was observed between CKD and AF (p for interaction = 0.015). CONCLUSION: The combined effect of AF and CKD on the risk of MACCE after an AMI is stronger than any separate condition, and it confers a synergistic effect on the all-cause mortality risk. |
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