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작성일 : 15-04-01 14:35
연구단계 1단계 : 2년차
논문제목(영문) Comparison of the effects of two low-density lipoprotein cholesterol goals for secondary prevention after acute myocardial infarction in real-world practice: ≥ 50% reduction from baseline versus <70 mg/dL.
국내외구분 국외 SCI여부 SCI
연구책임자역활 교신저자 논문기여율 30%
주저자명 Cho KH
교신저자명 Jeong MH
공동저자명 Park KW, Kim HS, Lee SR, Chae JK, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC
게제년월일 2015-03-26
ISSN 0167-5273
Impact Factor 6.175
학술지명 Int J Cardiol
서지사항 0집 / Epub권 / 0호,   페이지(0 - 0)
병기표기 단독
Acknowledgement
기재여부

※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정.
- 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)"
- 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project,
(HI13C1527) Ministry of Health & Welfare, Republic of Korea. "
요약초록문
(Abstract) 입력
Background
The present study compared the effects of two low-density lipoprotein cholesterol (LDL-C) goals for secondary prevention after acute myocardial infarction (AMI) in real-world practice.

Methods and Results
Of 3,091 consecutive patients with AMI who had baseline LDL-C levels ≥70 mg/dL and underwent successful percutaneous coronary intervention, 1,305 eligible patients who received discharge statin prescriptions were analyzed. Patients were categorized into 2 groups according to the values of LDL-C at 1 year in two different manners using percent reduction from baseline (≥50% reduction, n=428 versus <50% reduction, n=877) and fixed levels (<70 mg/dL, n=625 versus ≥70 mg/dL, n=680). The primary outcome was defined by the composite of 2-year major cardiac events including cardiac death, non-fatal myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting after hospital discharge. At 2 years, major cardiac events occurred in 139 patients (10.7%). Compared with <50% LDL-C reduction from baseline, patients with ≥50% LDL-C reduction had a 47% risk reduction in major cardiac events (adjusted hazard ratio, 0.53; 95% confidence interval, 0.36 to 0.79; P=0.002). But, compared with LDL-C levels ≥70 mg/dL at 1 year, patients with LDL-C levels <70 mg/dL at 1 year had a similar risk of major cardiac events (adjusted hazard ratio, 0.96; 95% confidence interval, 0.68 to 1.34; P=0.793).

Conclusions
Obtaining a ≥50% reduction in LDL-C was associated with better clinical outcomes after AMI in real-world practice, whereas achieving a <70 mg/dL was not.

 
Total 26
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26 Comparison of the effects of two low-density lipop… Cho KH Jeong MH Int J Cardiol
25 Impact of renal function on changes of plaque char… Hong YJ Jeong MH Int J Cardiol
24 Reliable femoral chronic total occlusion model usi… Kim NY, Lim KS Jeong MH J Mater Sci Mater Med
23 Cardioprotective effect of fimasartan, a new Angio… Sim DS Jeong MH J Korean Med SCI
22 Clinical significance of chronic kidney disease an… Hwang HS Ahn Y Am J Nephrol
21 Impact of postdischarge statin withdrawal on long-… Kim MC Ahn Y Am J Cardiol
20 Impact of low level of high-density lipoprotein-ch… JI MS Jeong MH J Cardiol
19 In vivo evaluation and characterization of a bio-a… Park SA Jeong MH, Park JK Materials Letters
18 Comparison of second-generation drug-eluting versu… Piao ZH Jeong MH Int J Cardiol
17 Current Trend of Acute Myocardial Infarction in Ko… Kook HY Jeong MH Am J Cardiol
16 Gallic acid inhibits vascular calcification throug… Kee HJ Jeong MH Vascul Pharmacol
15 Sulforaphane suppresses cardiac hypertrophy by inh… Kee HJ Jeong MH Mol Nutr Food Res
14 QRS morphology and ventricular dyssynchrony in pat… Lee KH Cho JG Int J Cardiol
13 Structural, optical, and selective ethanol sensing… C. Balamurugan Lee DW Sensor Actuat B-Chem
12 Fabrication of biomimetic PCL scaffold using rapid… SA Park SA Park Macromol Res
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